oa Southern African Journal of Anaesthesia and Analgesia - Herbal medications - harmless or harmful? : registrar prize



Garlic (Allium sativum) has been investigated for its antihypertensive effects, although these are short-lived (<2hrs in animal studies) and is not recommended for routine use. The main interest with garlic is its anticholesterol activity. Allicin, a thiosulphate is formed when the garlic bulb is crushed and it inhibits HMG - CoA, an enzyme important in the synthesis of cholesterol. RCTs suggest possible short-term beneficial effects in lowering lipid and cholesterol levels.


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