n Medical Technology SA - Breast cancer biomarkers : development, application and management
|Article Title||Breast cancer biomarkers : development, application and management|
|© Publisher:||The Society of Medical Laboratory Technologists of South Africa (SMLTSA)|
|Journal||Medical Technology SA|
|Author||Puleng R. Matatiele and Wilhelmina M.J. Van den Heever|
|Publication Date||Dec 2006|
|Pages||11 - 19|
At present, the most useful clinical biomarkers for breast cancer are the oestrogen / progesterone receptors and HER-2. The discovery of cancer biomarkers is currently a major focus of cancer research. Consequently, a large number of potential diagnostic and prognostic biomarkers for breast cancer are now known, although no single marker has so far proven useful as an independent method for breast cancer screening or diagnosis. This can be ascribed to the fact that many of these biomarkers have not yet been assessed in a reliable and reproducible way in order to determine their importance and usefulness in clinical patient management. Discovering biomarkers is a slow process, and numerous obstacles must be overcome in translating them from the research laboratory into clinical use. This paper gives an overview of the application of biomarkers in breast cancer management, the process of biomarker discovery and development and the future prospects regarding biomarker application in breast cancer management.
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