n Medical Technology SA - The structural biology of HIV




Since the identification of Acquired Immunodeficiency Syndrome (AIDS) in developed countries in the early 1980's, efforts to control the AIDS epidemic have focused heavily on studies of the biology, biochemistry, structural biology of human immunodeficiency virus (HIV) and on interactions between viral components and new drug candidates. HIV-1 is a very complex pathogen and encodes three structural proteins, two envelope proteins, three enzymes, and six accessory proteins. Due to the great deal of emphasis placed on drug therapy in the past decade a good review regarding the structural biology of the virus can only be advantageous. This review is an attempt to integrate structural and biochemical information into a view of the HIV-1 particle as a whole, emphasizing key interactions among viral and cellular components during the viral replication cycle.


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