n Medical Technology SA - Oral antihyperglycaemic agents in diabetes; correlation of HbA1c and biochemical analytes of microvascular renal involvement : peer reviewed short article
|Article Title||Oral antihyperglycaemic agents in diabetes; correlation of HbA1c and biochemical analytes of microvascular renal involvement : peer reviewed short article|
|© Publisher:||The Society of Medical Laboratory Technologists of South Africa (SMLTSA)|
|Journal||Medical Technology SA|
|Author||Jamila Khatoon Adam, Ashraff Yousouf Moosa and Wafaa Saieed Rmaih|
|Publication Date||Dec 2009|
|Pages||16 - 18|
|Keyword(s)||Creatinine, Glycocylated haemoglobin, Metformin, Sulfonylureas and Urine microalbumin|
Background: This was a pilot study that aimed to perform a statistical correlation between glycocylated haemoglobin (HbA1c) levels and biochemical predictors of renal involvement in type 2 diabetic patients, namely, serum creatinine and urine microalbumin, in diabetes type 2 patients treated oral antihyperglycaemics. The biochemical measurements were also correlated with the patients' age, duration of diabetes and their body weight.
Methods: The study was performed at the Centre of Diabetes and Endocrinology, Pietermaritzburg, South Africa. A sample of 43 diabetes type 2 patients (23 females and 20 males), age (33-74 yrs), body weight (46Kg-121.5Kg), and duration of diabetes (1-22 years) participated in this study. All patients were on treatment with one or a combination of Sulfonylurea and / or the Biguanide compounds. Laboratory measurements of HbA1c, serum creatinine and urine microalbumin were done for each patient.
Results: There was no statistical correlation between HbA1c and either serum creatinine or urine microalbumin, nor between the biochemical analytes and patients' age, body weight and duration of diabetes.
Conclusions: Although we cannot generalise the results of this study because of the limited patient sample, the possible explanations for our results could be the biological variation of HbA1c, plasma glucose variability affecting results of HbA1c measurements or physiologic sources of variation in diabetic complications beyond glycemic control.
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