n Medical Technology SA - Fructosamine assays in relationship with glycosylated hemoglobin (HbA1c) and plasma glucose in diabetic patients and a normal control group : peer reviewed original article
|Article Title||Fructosamine assays in relationship with glycosylated hemoglobin (HbA1c) and plasma glucose in diabetic patients and a normal control group : peer reviewed original article|
|© Publisher:||The Society of Medical Laboratory Technologists of South Africa (SMLTSA)|
|Journal||Medical Technology SA|
|Author||M.J. Dreyer and W.J. Badenhorst|
|Publication Date||Dec 2010|
|Pages||33 - 36|
|Keyword(s)||Fructosamine, Glycaemic control, HbA1c and University of Limpopo|
Diabetes Mellitus is a serious metabolic disorder characterized by a tendency to chronic hyperglycaemia with disturbance in carbohydrate, fat and protein metabolism that arise from a defect in insulin secretion, or action, or both. It is a common condition, with a prevalence of approximately 4% in the Western world. Early diagnosis is essential as well as the monitoring of glycaemic control. A correlation between HbA1c and fructosamine as indicator of glycaemic control is demonstrated in a group of 20 adult diabetic patients treated with antihyperglycaemics and a group of 20 adult normal individuals. The significance of this study is to determine if both HbA1c and fructosamine assays are necessary for the evaluation of glycaemic control in diabetic patients. Also, a correlation study between two automated instruments using the same fructosamine reagent kit was done, with no significant difference between the two methods. Our conclusion from this study is that only one standard indicator (e.g. only HbA1c) of glycaemic control in diabetic patients is advisable because of many patient to patient and other variables.
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