n Medical Technology SA - Pathogenesis and future treatments of systemic lupus erythematosus : the role of cytokines and anti-cytokines? : peer reviewed review
|Article Title||Pathogenesis and future treatments of systemic lupus erythematosus : the role of cytokines and anti-cytokines? : peer reviewed review|
|© Publisher:||The Society of Medical Laboratory Technologists of South Africa (SMLTSA)|
|Journal||Medical Technology SA|
|Affiliations||1 University of Johannesburg|
|Publication Date||Jun 2011|
|Pages||5 - 17|
Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune connective tissue disorder, which has variable clinical manifestations that range from mild to life-threatening. These can be characterised by multiple organ damage, very high titres of autoantibodies and immune complex deposition. Interestingly the former of these characteristics may precede the clinical manifestations of SLE by many years. It is well recognised that the probable influence of oestrogen hormonal effect in women during childbearing years increases their chances of developing SLE by 10-15 times.
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