n Medical Technology SA - Evaluation of the antimutagenic and mutagenic properties of : peer reviewed original article




Several medicinal plants are traditionally used in the treatment of a variety of ailments including cancer in the rural areas of South Africa and our neighbouring countries where herbal medicine is one of the main components of the healthcare system. Many of these herbs, including , have not been scientifically assessed for efficacy or safety. The study on which this article is based evaluated the antimutagenic and mutagenic water extract of roots used in the treatment of cancer. The Ames test recommended for mutagenicity screening was employed. The mutagenic activity was evaluated in strains TA97, TA98, TA100 and TA102. The mutagenicity tests of aqueous extracts were negative throughout (1:10, 1:25, 1:50. 1:100, and 1:200). The highest antimutagenic effect in the order of 49% was observed using TA 98 (5μg daunomycin/plate), a strong mutagen. These results indicate the potential for use of this plant against cancer and oxidative stress-related diseases.


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