n Medical Technology SA - Comparison of three methods for procalcitonin analysis : peer reviewed original article
|Article Title||Comparison of three methods for procalcitonin analysis : peer reviewed original article|
|© Publisher:||The Society of Medical Laboratory Technologists of South Africa (SMLTSA)|
|Journal||Medical Technology SA|
|Affiliations||1 University of the Free State and 2 University of the Free State|
|Publication Date||Jun 2012|
|Pages||48 - 52|
|Keyword(s)||BRAHMS Kryptor(R) PCT, Immunoassay, Procalcitonin, Roche Elecsys(R) PCT and Siemens ADVIA Centaur(R) PCT|
Introduction Procalcitonin (PCT) is a biomarker used in the diagnosis and management of bacterial infection and sepsis. The BRAHMS Kryptor® PCT assay was the first automated assay on the market and was cleared by the FDA in 2008. Siemens and Roche Healthcare diagnostics have partnered with BRAHMS, and their automated PCT assays are now available in South Africa.
Aim and Methods The aim of this study was to compare different aspects of the Siemens ADVIA Centaur® PCT and Roche Elecsys® PCT assays with the existing BRAHMS Kryptor® PCT assay and to evaluate the analytical performance of the three different methods.
Results and Conclusion Although the three PCT assays differ in sample volume required, measuring range, dilution capacity and analysis time, the two new PCT methods from Siemens and Roche correlate well with the existing Kryptor PCT method.
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