n Medical Technology SA - Expression of p63, p504S and androgen receptor status in salivary gland carcinomas : a study of 32 cases : peer reviewed original article
|Article Title||Expression of p63, p504S and androgen receptor status in salivary gland carcinomas : a study of 32 cases : peer reviewed original article|
|© Publisher:||The Society of Medical Laboratory Technologists of South Africa (SMLTSA)|
|Journal||Medical Technology SA|
|Affiliations||1 University of Limpopo, 2 University of Limpopo, 3 University of Limpopo and 4 University of Limpopo|
|Publication Date||Jun 2012|
|Pages||18 - 21|
|Keyword(s)||Androgen receptors, Immunohistochemistry, p504S, p63 and Salivary neoplasm|
Immunostaining for p63, p504S and the androgen receptor status are important markers for carcinomas of the prostate. The purpose of this study was to investigate the staining characteristics of these markers for malignancies of salivary gland origin. Wax blocks of 32 malignant salivary gland neoplasms were retrieved, sections prepared and stained by the H&E method and immunoperoxidase techniques for the demonstration of p63 (Dako N1604), p504S (Dako N1609) and androgen receptors (Dako M3562). The sections were viewed by light microscopy and positivity scored with the aid of a grading scale. Androgen receptor- and p504S positivity were infrequently observed in the study samples, except for salivary duct carcinoma and mucoepidermoid carcinoma where most of the cases stained positive for p504S. The staining pattern of adenoid cystic carcinomas for p63 correlated with the microscopic subtype. The basal- and intermediate cells of mucoepidermoid carcinomas stained positive- and the mucus- and epidermoid cells negative for p63. All acinic cell adenocarcinomas stained negative- and most clear cell carcinomas and epimyoepithelial carcinomas positive for p63. The role of these markers in the diagnosis and prognostication of malignancies of salivary gland origin is discussed.
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