n Medical Technology SA - The effect of Tenofovir on renal function in HIV-positive patients in Lesotho : peer reviewed original article
|Article Title||The effect of Tenofovir on renal function in HIV-positive patients in Lesotho : peer reviewed original article|
|© Publisher:||The Society of Medical Laboratory Technologists of South Africa (SMLTSA)|
|Journal||Medical Technology SA|
|Affiliations||1 National University of Lesotho, 2 Central University of Technology, 3 Central University of Technology and 4 Central University of Technology|
|Publication Date||Jun 2014|
|Pages||34 - 38|
|Keyword(s)||Lesotho, Renal impairment, TDF and Tenofovir|
Lesotho introduced tenofovir disoproxil fumarate (TDF) for first-line antiretroviral treatment (ART) in 2008. The use of TDF has been associated with renal toxicity. The study utilised an analytical design to compare retrospective creatinine clearance (CrCl) data of 312 antiretroviral treatment naïve adults exposed to TDF and 173 unexposed patients. Impaired renal function was defined as CrCl<50 ml/min calculated using the Cockcroft-Gault equation. In fifty-six patients (17.9%) TDF was found to be contraindicated. The use of TDF was marginally significant factor for renal toxicity (p=0.054) in univariate analysis, but was insignificant (p=0.122) in multivariate logistic analysis. Univariate (p<0.1) and multivariate logistic regression (p<0.05) were performed using STATA® 11. Female gender (p=0.016), hypertension (p=0.009), and age > 60 (p=0.004) were significantly associated with CrCl<50 ml/min outcome. TDF is a weak contributing factor to renal impairment. Routine baseline renal function screening should be adopted to prevent patients with impaired renal function receiving TDF.
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