n Evidence Based Summaries in Dentistry - Naïve-indirect comparison of two competing interventions gives unreliable results




The process of comparison has been defined as an estimate of the similarities/dissimilarities between two things or people. In health sciences, the outcome of comparisons concerning the effectiveness of clinical interventions relies on the inference that any observed higher treatment effect of one intervention above another is indeed attributable to the characteristics of such treatment. Therefore, conditions of comparisons should assure an even distribution of all factors among the compared intervention groups, with the exception of the differences in intervention that are related to the outcome of interest. Such even distribution of confounding factors can be achieved by random subject allocation to intervention groups.


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