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n Journal of Minimum Intervention in Dentistry - Effect on pulp tissue of resin-modified GlC versus compomers - a quantitative systematic review
Objectives To assess whether resin-modified glass ionomer cements have a similar effect on pulp tissue than compomers.
Search strategy The trials were identified from a search of the PubMed database on 8 January 2010 using the terms: ((("Compomers"[Mesh] AND "Glass lonomer Cements"[Mesh]) OR "glass ionomer "[Substance Name])) AND "Dental Pulp"[Mesh]. References of accepted articles were checked for additional studies suitable for inclusion.
Inclusion criteria 2-arm prospective longitudinal trial (in vitro, in situ, in vivo) with relevance to review question including computable data; published in English.
Data collection and analysis The systematic literature search found 10 trials of which 3 in vitro trials were identified to be in line with the inclusion criteria. From the reviewed trials 14 individual datasets were extracted. No meta-analysis was possible due to clinical methodological heterogeneity.
Main results The results of the 14 (in vitro) datasets are conflicting. Both type of materials appear to act cytotoxic on pulp cells at various degrees. The strength of this effect appears to be depended on the individual chemical composition of each Compomer or RMGlC product and its subsequent ability to release toxic components after curing. Further in-vitro trials are needed to clarify whether Compomers and resin-modified glass ionomer cement differ in their cytotoxicity as such.
Conclusions Both type of materials appear to act cytotoxic in vitro. In order to answer the review question clinically, high quality randomized-control trials (RCT) are required.
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