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- Journal of Minimum Intervention in Dentistry
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- Volume 4, Issue 4, 2011
Journal of Minimum Intervention in Dentistry - Volume 4, Issue 4, 2011
Volume 4, Issue 4, 2011
Source: Journal of Minimum Intervention in Dentistry 4, pp 77 –83 (2011)More Less
Saliva testing, a non-invasive alternative to serum testing, may be an effective modality for diagnosis and for prognosis prediction of oral cancer, as well as for monitoring post therapy status, by measuring specific salivary macromolecules, examining proteomic or genomic targets such as enzymes, cytokines, growth factors, metalloproteinases, endothelin, telomerase, cytokeratines, mRNA's and DNA transcripts. Salivary analysis has been shown to be a useful diagnostic tool also for distant malignancies such as breast cancer. In recent years, significant alterations have been demonstrated in the saliva of oral cancer patients in the epithelial tumor markers - Cyfra 21-1, TPS and CA12, various oxidative stress-related salivary parameters as ROS and RNS, biochemical and immunological parameters as IGF and MMP's and RNA transcripts of IL8, IL-1B, DUSP1, HA3, OAZ1, S100P, and SAT. Collectively these accumulated data are predicted to alter the field of oral cancer diagnosis by employing highly sensitive new tools which will enable both medical professionals and the patients themselves to monitor their saliva for diagnosis and prognosis prediction, as they relate to oral cancer. At this point however, the aim of salivary analysis is mainly for screening which may be helpful in the future. This article reviews on role of saliva in detection of oral cancer.
Source: Journal of Minimum Intervention in Dentistry 4, pp 84 –87 (2011)More Less
The purpose of a systematic review on the caries-preventive effect of glass ionomer and resin-based fissure sealants on permanent teeth was to appraise the evidence on the caries-preventive effect of glass ionomer cement (GIC) in relation to resin-based fissure sealants. The investigation, which included a meta-analysis, found no evidence that either material was superior to the other in the prevention of dental caries. Thus, both materials appear equally suitable for clinical application as a fissure sealant material. Apex spoke with one of the review authors, Dr Steffen Mickenautsch, about the study and the results.
Author S. MickenautschSource: Journal of Minimum Intervention in Dentistry 4, pp 88 –89 (2011)More Less
Much of a minimally invasive future in dentistry does depend on how accurately disease risk assessment can predict future disease, how sensitive our MI diagnostic tools are in order to really catch oral disease at the earliest point in time and how long an MI tooth restoration lasts in comparison to traditional and more invasive approaches. Currently, the best solution is to consult systematic reviews. Systematic reviews are specifically designed to rigorously appraise scientific studies. They include a systematic search of all studies available on a particular topic worldwide. Systematic reviews assess the risk of systematic error in each study (also known as bias) and combine, whenever possible, the results of those with least error for greater precision.
Source: Journal of Minimum Intervention in Dentistry 4, pp 90 –91 (2011)More Less