n Journal of Minimum Intervention in Dentistry - Does GIC have any cariostatic effect? [2008] : grey literature




[This document has been captured as part of the JMID-section for Grey-literature. Grey (or gray) literature refers to informally published written material that may be difficult to trace via conventional databases and/or journals as it is not formally published or is not widely accessible. However, Grey literature may still be an important source of information. Examples of grey literature include e.g.: patents, reports, working documents or unpublished manuscripts]

The systematic literature search identified 63 articles in compliance with the broad inclusion criteria. Of these, 28 articles were rejected due to insufficient internal validity. Thirty-five articles were accepted, 6 of which were systematic reviews. Twenty-nine trials were accepted for data extraction and further meta-analysis. Before heterogeneity was assessed among trials, dichotomous data of the accepted trials were pooled, indicating a weighted odds ratio (OR = Global results) of 1.32 (CI 95% 1.10 - 1.58). This means that GIC appears to increase the odds of being caries free by 32%. The observation that GIC has an anticariogenic effect, as compared to other materials, is supported by available continuous data for restorations and orthodontic cementation. The available continuous data for fissure sealants confirms the observation that low viscosity GIC and resin-based fissure sealants do not differ in their caries preventive effect. These finding are also in line with the results of most rejected trials but not with the conclusions of most of the accepted systematic reviews by other authors. Clinical heterogeneity was observed and articles grouped accordingly, yielding separate results (see section "4. Heterogeneity and META analysis"). In order to confirm the global results further randomized control trials are needed. It is recommended that reporting of such studies should follow the CONSORT statement.


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