n Journal of Minimum Intervention in Dentistry - In deep cavities of comparable size, is RMGIC as a liner less biocompatible to pulp tissue than calcium hydroxide? [2008] : grey literature




[This document has been captured as part of the JMID-section for Grey-literature. Grey (or gray) literature refers to informally published written material that may be difficult to trace via conventional databases and/or journals as it is not formally published or is not widely accessible. However, Grey literature may still be an important source of information. Examples of grey literature include e.g.: patents, reports, working documents or unpublished manuscripts]

The systematic literature search identified 11 articles including 55 separate data sets with relevance to the review question. The results of 49 data sets suggest that RMGIC is at least as biocompatible to pulp tissue as calcium hydroxide and the results of 6 data sets from studies on human tissue indicate that calcium hydroxide is more biocompatible than RMGIC in regard to inflammatory cell response, hard tissue formation and odontoblast changes. However, the evidence provided by all trials has to be regarded as too weak to draw any firm conclusions due to potential influence of bias and subsequent possible overestimation of the RMGIC treatment effect. High quality randomized control trials are needed to validate current results. It is recommended that reporting of such future studies should follow the CONSORT statement.


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