oa Professional Nursing Today - Use of amikacin in neonates and related ototoxicity : neonatology

Volume 17, Issue 1
  • ISSN : 1607-6672



Neonates frequently receive aminoglycosides as empiric therapy for severe infections caused by suspected Gram-negative bacteria. Amikacin is classified as an aminoglycoside. Optimum dosing of aminoglycosides is required because of the inter-individual variability in the pharmacokinetics of aminoglycosides in the neonatal population. Aminoglycosides have the ability to produce nephrotoxicity and ototoxicity. This is a major limitation and concern regarding the use of this class of antibiotics. The ototoxic effects of AG treatment are dose-dependent. Preterm infants are especially susceptible to the ototoxic effects of aminoglycoside drugs, because of the anatomical and functional maturation development of the inner-ear system. Identification of AG ototoxicity is important to minimise long-term damage.

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