oa Professional Nursing Today - Use of amikacin in neonates and related ototoxicity : neonatology
|Article Title||Use of amikacin in neonates and related ototoxicity : neonatology|
|© Publisher:||Medpharm Publications|
|Journal||Professional Nursing Today|
|Affiliations||1 University of Limpopo, 2 University of Limpopo, 3 University of Limpopo and 4 University of Limpopo|
|Publication Date||Jan 2013|
|Pages||24 - 27|
|Keyword(s)||Amikacin, Neonates and Related ototoxicity|
Neonates frequently receive aminoglycosides as empiric therapy for severe infections caused by suspected Gram-negative bacteria. Amikacin is classified as an aminoglycoside. Optimum dosing of aminoglycosides is required because of the inter-individual variability in the pharmacokinetics of aminoglycosides in the neonatal population. Aminoglycosides have the ability to produce nephrotoxicity and ototoxicity. This is a major limitation and concern regarding the use of this class of antibiotics. The ototoxic effects of AG treatment are dose-dependent. Preterm infants are especially susceptible to the ototoxic effects of aminoglycoside drugs, because of the anatomical and functional maturation development of the inner-ear system. Identification of AG ototoxicity is important to minimise long-term damage.
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