oa South African Family Practice - Medifile : ACE-inhibitors versus angiotensin receptor blockers in renal and cardiovascular protection in diabetic patients



Extracted from text ... October 2005; 19(10) ACE-INHIBITORS VERSUS ANGIOTENSIN RECEPTOR BLOCKERS IN RENAL AND CARDIOVASCULAR PROTECTION IN DIABETIC PATIENTS SA Fam Pract 2005;47(10) 32 Figure 2 B1 B2 renin Angiotensinogen Angiotensin I AT2 AT1 ACE ACE Inactive fragments Bradykinin Angiotensin lI - ARBs Slight increase EDITORIAL Hypertension presents a major risk factor for cardiovascular morbidity and mortality in patients with diabetes.1 Blockade of the renin-angiotensin system by either angiotensin-converting enzyme (ACE) inhibition or angiotensin receptor blockade (ARB) has cardiovascular and reno-protective effects. However, there is still much controversy over which of the two drug classes offers more protection.2 This article takes a ..


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