oa South African Family Practice - The treatment of cholesterol : issues, effects and targets : review
|Article Title||The treatment of cholesterol : issues, effects and targets : review|
|© Publisher:||Medpharm Publications|
|Journal||South African Family Practice|
|Publication Date||Nov 2010|
|Pages||523 - 524|
|Keyword(s)||University of Pretoria|
Statins are the most powerful cholesterol lowering drugs currently available. Statins inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) reductase, which leads to reduced cholesterol synthesis. In addition, low-density cholesterol receptors on the hepatocyte surface are upregulated, leading to increased clearance of cholesterol. The end result is a significant reduction in cholesterol levels, and a consequent significant reduction in mortality and cardiovascular events in the appropriate individual.
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