oa South African Family Practice - A ten-year histopathological study of generalised lymphadenopathy in India : original research



: Lymphadenopathy is a rather common clinical finding in a primary healthcare setting, and may be due to inflammatory lesions and tumours. Correlation between clinical findings and laboratory data is essential in arriving at a diagnosis. This study was undertaken to study the histopathology of generalised lymphadenopathy in India, as well as the demographics of the study population.

: This study was conducted for a period of 10 years (August 1997 - July 2007), of which eight years were retrospective, from August 1997 - July 2005, and two years were prospective, from August 2005 - July 2007. The source of data for this study was patients seeking medical attention, who, on clinical examination, were found to have generalised lymphadenopathy. A representative node was excised for histopathology. Tissues were routinely processed, stained with haematoxylin and eosin, and examined by means of light microscopy.
: Of the 244 lymph node biopsies analysed in this study, 75 cases (30.73%) were reactive lymphadenitis, 142 cases (58.19%) showed granulomatous lymphadenitis, one case (0.40%) was Hodgkin's lymphoma, eight cases (3.27%) were non-Hodgkin's lymphoma, and 18 cases (7.37%) were metastatic malignancy.
: In this study, the most common cause of generalised lymphadenopathy was granulomatous lymphadenitis, followed by reactive lymphadenitis. Among the neoplastic lesions, metastatic malignancy accounted for most cases.


Article metrics loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error