oa South African Family Practice - The effects of corticosteroids and nonsteroidal anti-inflammatory drugs, including aspirin, on coagulation : review
|Article Title||The effects of corticosteroids and nonsteroidal anti-inflammatory drugs, including aspirin, on coagulation : review|
|© Publisher:||Medpharm Publications|
|Journal||South African Family Practice|
|Affiliations||1 Inkosi Albert Luthuli Central Hospital|
|Publication Date||Sep 2015|
|Pages||9 - 12|
|Keyword(s)||Coagulation, Corticosteroids, Nonsteroidal anti-inflammatory drugs and NSAIDs|
The immune and coagulation systems have numerous interactions, as evidenced by the increased risk of venous thromboembolism in inflammatory bowel disease. In general, proinflammatory states are prothrombotic, while a reduction in inflammation reduces thrombotic risk. Corticosteroids, such as hydrocortisone and prednisone, tend to reduce inflammation and thus thrombosis, while being prothrombotic in non-inflammatory states, e.g. Cushing's syndrome. The nonsteroidal anti-inflammatory drugs also have a dual effect, through interaction with different cyclo-oxygenase enzyme isoforms, on platelets and the vascular endothelium.
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