oa Southern African Journal of Epidemiology and Infection - Epidemiology of neonatal sepsis at Johannesburg Hospital
|Article Title||Epidemiology of neonatal sepsis at Johannesburg Hospital|
|© Publisher:||Medpharm Publications|
|Journal||Southern African Journal of Epidemiology and Infection|
|Author||F. Motara, D.E. Ballot and O. Perovic|
|Publication Date||Jan 2005|
|Pages||90 - 93|
We evaluated sepsis in the neonatal unit at Johannesburg Hospital including the time of onset, clinical features, outcome of the treatment of patients, pathogens isolated, and antimicrobial sensitivity to provide site-specific guidelines for empiric antibiotic therapy. This was a retrospective study conducted in the neonatal unit of the Johannesburg Hospital between 1 July 2002 and 30 June 2003. All neonates with growth on blood cultures were included. Demographic, clinical, laboratory and microbiological data were reviewed. Of a total of 103 infants with 140 positive blood cultures, eight isolates were most likely to be contaminants. There were thus 132 significant isolates in 96 patients : five presented with early onset sepsis (EOS) and 91 with late onset sepsis (LOS). Gram-negative bacilli were the predominant isolates in EOS and coagulase-negative staphylococci (CoNS) the predominant isolates (63) in LOS (40/63 considered significant, CoNS were not speciated as Staphylococcus epidermidis). The remaining isolates in LOS were mostly Gram-negative organisms. The case fatality rate was 40% for EOS and 19.7% for LOS. Multiresistant sensitivity patterns (resistance to < 2 classes of antibiotics) were identified in 45 organisms (34.5 %). LOS was more common than EOS in the Johannesburg Hospital neonatal unit but had a lower case fatality rate.
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