oa Southern African Journal of Epidemiology and Infection - Comparative activity of generic injectable cephalosporins



The activily of the generic forms of cefotoxine, cefirioxone, cefuroxime, cefazolin and cefoxitin, supplied by South African pharmaceutical company Aspen Pharmacare, was compared with that of Rocephin, Zinacef, Kefzot and Mefaxin, Minimum inhibitory concentrations, (MICs) were determined using a microtitre broth dilution technique, according to CLSI recommendations. The of the Aspen Pharmacare generic agents was found to be comparable to that of the originator drugs. The MICs of each generic agent were within two doubling dilutions of the originator drug, respectively.


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