oa Southern African Journal of Epidemiology and Infection - Detection of with reduced susceptibility to vancomycin in a South African teaching hospital

Volume 20, Issue 4
  • ISSN : 1015-8782
  • E-ISSN: 2220-1084



Fifty-six methicillin-resistant clinical isolates were collected over a two-month period from a large teaching hospital in Pretoria, South Africa. Isolates were subjected to screening and confirmatory testing for vancomycin hetero-resistance. Thirty-three isolates were identified with the macro-method Etest as possibly being hetero-resistant to vancomycin. Twenty randomly selected hetero-resistant isolates were subjected to population analysis profile, area under the curve ratio methodology, of which 18 were confirmed to be vancomycin hetero-resistant. As a screening test, the macro-method Etest thus exhibited high sensitivity and specificity, for detecting hetero-resistant at this institution.

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