oa Southern African Journal of Epidemiology and Infection - Susceptibility of Bacillus anthracis to moxifloxacin : short communication
A study was conducted to determine the relative susceptibilities of Bacillus anthracis to ciprofloxacin compared to moxifloxacin, an agent with enhanced potency against other Gram-positive pathogens. The minimum inhibitory concentrations (MICs) of 51 isolates of B. anthracis from southern African countries, as well as the Sterne vaccine strain, were determined by broth microdilution. All isolates were susceptible to the two quinolones, but ciprofloxacin was slightly more active than moxifloxacin. All isolates were susceptible to doxycycline. Moxifloxacin offers no MIC advantage over ciprofloxacin for the management of wild type infections caused by B. anthracis.
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