oa Southern African Journal of Epidemiology and Infection - Antibiotic susceptibility patterns of anaerobic bacteria isolated in Pretoria, South Africa, during 2003-2004
Antibiotic resistance amongst previously susceptible anaerobic bacteria has increased during the last decade, raising concerns about the choice of empirical therapy. In this study, Etest methodology and Clinical Laboratory Standards Institute guidelines were used for processing and interpretation of minimum inhibitory concentration values for anaerobic bacteria obtained over a one-year period from two teaching hospitals in Pretoria, South Africa. From the data obtained, the genera Bacteroides, Clostridium and Peptostreptococcus were most frequently isolated. The β-lactam/β-Iactamase inhibitor combination, piperacillin/tazobactam seems to be the superior choice as empiric therapy for suspected serious anaerobic infections in this setting. In addition, a definite increase in resistance against metronidazole was exhibited by isolates originating from invasive samples, making the drug an unlikely choice for future empiric therapy.
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