oa Southern African Journal of Epidemiology and Infection - Rotarix : example of a recently developed oral vaccine against rotavirus for infants
Rotavirus gastroenteritis (RVGE) is the leading cause of severe diarrhoeal disease in infants and young children between 6-24 months of age world-wide. Prospective epidemiological studies have shown that already 20% of acute rotavirus gastroenteritis occurs during the first 6 months of life. It has recently been estimated that world-wide in children under 5 years of age, 611,000 (range 454,000-705,000) rotavirus-related deaths occur each year, with the majority of these deaths occurring in developing countries the Asian subcontinent, Africa, and Latin America. Every year in Africa, rotavirus is estimated to cause 170,000 to 210,000 deaths in children under 5 years of age and approximately 145,000 of these deaths occur in sub-Saharan Africa alone. In other low-income countries such as Bangladesh, rotavirus is estimated to cause 6,000-14,000 deaths each year in children under 5 years of age, whereas in India, up to a 100,000 deaths are recorded every year.
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