oa Southern African Journal of Epidemiology and Infection - An unusual case of fatal gastrointestinal Rhizopus oryzae infection in a diabetic patient : case report
Zygomycoses (mucormycoses) are rare, angiotropic infections caused by fungi in the class Zygomycetes of the order Mucorales. This paper reports a case of a mildly obese patient with uncontrolled type 2 diabetes mellitus who was admitted with symptoms of sinusitis. At admission she presented with a hyperosmolar, non-ketotic coma and metabolic acidosis. Six days after admission, following a cardiac arrest, the patient was transferred to the multi-disciplinary intensive care unit. She initially had a low Glascow coma scale. Computerised tomography of the brain and nasopharyngeal lavages showed no signs of mucormycosis or brain abscess and sinusitis was confirmed. Gastroscopy and laparotomy revealed disseminated necrosis and infiltrates of the gastrointestinal tract which was confirmed as mucormycosis by microbiological and histological investigations. This extensive gastrointestinal and multi-organ invasion resulted in demise of the patient 12 days after admission.
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