oa Southern African Journal of Epidemiology and Infection - Evidence of an inverse relationship between cytotoxin-associated gene A-positive infection and oesophageal adenocarcinoma and possible geographical implications : correspondence

Volume 24, Issue 4
  • ISSN : 1015-8782
  • E-ISSN: 2220-1084



Over the past 50 years there have been marked changes in the prevalence of upper gastrointestinal diseases in the Western world. Oesophageal adenocarcinoma (OAC) is the most rapidly increasing cancer in the United States today and is increasing at the rate of ~10% each year in the developed world. It is predicted that if this trend goes unchecked OAC will become the predominant cancer of this century. This type of cancer is usually preceded by gastro-oesophageal reflux disease (GORD) and a pre-cancerous condition known as Barrett's metaplasia in which columnar epithelial cells of the lower oesophagus grow abnormally and show metaplastic changes.

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