oa Southern African Journal of Epidemiology and Infection - The quest to understand protective immunity to HIV-1 through studies on maternal-infant HIV-1 transmission : Festschrift

Volume 26, Issue 4
  • ISSN : 1015-8782
  • E-ISSN: 2220-1084



Understanding immune processes that contribute to how some human hosts prevent the establishment of human immunodeficiency virus type 1 (HIV-1) infection upon exposure, or counter accelerated disease progression if infected, will provide the basis for the design of better-targeted interventions to curb HIV-1 infection. There is little doubt that new immune targets need to be identified aside from the usual emphasis on cytotoxic T lymphocyte and neutralising antibody responses, classic favourites and hallmark responses of the adaptive immune system. However, potential contenders reside within the innate immune system, a component under-studied by comparison and one that increasingly is not "playing by the rules" and delivering some welcome surprises.

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