oa Southern African Journal of Epidemiology and Infection - Amphotericin B in the management of fungal infections in a neonatal intensive care unit : experiences in a teaching hospital : original research

Volume 27, Issue 1
  • ISSN : 1015-8782
  • E-ISSN: 2220-1084



Invasive systemic fungal infections have emerged as serious nosocomial threats to neonates in the neonatal intensive care unit (NICU). Candidaemia due to fluconazole-resistant Candida-krusei necessitated the use of amphotericin B in the NICU at Dr George Mukhari Hospital. The use of amphotericin B 1 mg/kg/dose in the first 20 patients was monitored. Response to treatment and side effects related to the use of amphotericin B in this population were documented and described. Nephrotoxicity, a common and well described side effect of amphotericin B, was not observed in this study - rather hepatotoxicity. To ensure uniformity in monitoring adverse effects, a monitoring tool has been developed for use in the NICU.

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