oa Southern African Journal of Epidemiology and Infection - Amphotericin B in the management of fungal infections in a neonatal intensive care unit : experiences in a teaching hospital : original research
|Article Title||Amphotericin B in the management of fungal infections in a neonatal intensive care unit : experiences in a teaching hospital : original research|
|© Publisher:||Medpharm Publications|
|Journal||Southern African Journal of Epidemiology and Infection|
|Affiliations||1 University of Limpopo, 2 University of Limpopo, 3 University of Limpopo, 4 University of Limpopo and 5 University of Limpopo|
|Publication Date||Jan 2012|
|Pages||24 - 29|
Invasive systemic fungal infections have emerged as serious nosocomial threats to neonates in the neonatal intensive care unit (NICU). Candidaemia due to fluconazole-resistant Candida-krusei necessitated the use of amphotericin B in the NICU at Dr George Mukhari Hospital. The use of amphotericin B 1 mg/kg/dose in the first 20 patients was monitored. Response to treatment and side effects related to the use of amphotericin B in this population were documented and described. Nephrotoxicity, a common and well described side effect of amphotericin B, was not observed in this study - rather hepatotoxicity. To ensure uniformity in monitoring adverse effects, a monitoring tool has been developed for use in the NICU.
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