1887

oa Southern African Journal of Epidemiology and Infection - Hepatitis C virus infection in 2012 and beyond : review

 

Abstract

Hepatitis C virus infection is estimated to affect 150 million people worldwide. A large number of individuals are chronically infected and are at risk of developing chronic liver disease, cirrhosis and hepatocellular carcinoma. Chronic hepatitis C infection causes significant morbidity and mortality. It is the leading indication for liver transplantation in the USA and Europe, and accounts for 30-50% of liver transplants in those countries. The introduction of blood and blood product screening protocols in 1992 led to a decline in new infections, but intravenous drug abuse still remains a major risk factor for acquiring the disease. Since no vaccine is available to prevent infection with this virus, research has been ongoing to find a cure. Treatment of hepatitis C has continuously evolved since the introduction of interferon monotherapy in the early 1990s, with very low response rates. In 2002, the use of pegylated interferon and ribavirin significantly improved sustained virological response rates to 50-80%. The management of patients who do not respond to standard care remains challenging. The US FDA approved directly acting antivirals in May 2011. This introduced a new era with regard to management of this condition.

Loading

Article metrics loading...

/content/mp_sajei/27/3/EJC125665
2012-01-01
2016-12-08
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error