oa Southern African Journal of Epidemiology and Infection - Prevalence of and allelic variants and associated disease outcomes in Kenyan patients with dyspepsia : original research



Although has been linked to various gastric disorders in Western countries and Asia, its aetiopathological role in African populations is controversial. The aim of this study was to investigate the role of and its virulence genotypes in gastrointestinal diseases in Kenyan patients with dyspepsia. Gastric biopsy specimens were obtained for DNA isolation and histopathological analysis. Amplification was performed using specific oligonucleotide primers. positivity was determined by stool antigen test, rapid urease test, and histology and molecular diagnostic tools. was detected with high frequency in patients with gastritis, peptic ulcer disease (PUD) and gastro-oesophageal reflux disease. This implies a significant risk of the development of these pathologies (p-value = 0.0000 in all cases). strains with occurred more frequently in PUD (65.2%). s1a genotype appeared to play a more significant pathological role (82.6% PUD) than the other variants (p-value = 0.0142). The prevalence of m1 was significantly higher in gastritis cases (p-value = 0.0253). m2 was found to be significantly associated with gastritis (p-value = 0.0253). This finding may point to the fact that m1 and m2 are independently associated with an increased risk for gastritis. Indications are that prevalence in Kenya may be declining. The independently occurring genotypes, as opposed to simultaneous carriage, could be the reason for the low distribution of pathologies.


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