oa Southern African Journal of Epidemiology and Infection - What is the link between vitamin D and tuberculosis? : review

Volume 28, Issue 4
  • ISSN : 1015-8782
  • E-ISSN: 2220-1084



Tuberculosis is one of the leading causes of morbidity and mortality globally. Vitamin D directly influences the body's immunological response to tuberculosis by modulating the production of certain antimicrobial peptides and the release of cytokines. Vitamin D deficiency has been extensively described in patients with tuberculosis. Currently, it is a recognised risk factor for tuberculosis. Genetic polymorphisms of the vitamin D receptor may influence host susceptibility to tuberculosis and response to antituberculosis therapy. This review article explores the close association between tuberculosis and vitamin D, with the aim of forming a strong basis for further interventional and genetic studies on patients with active tuberculosis.

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