oa Southern African Journal of Epidemiology and Infection - What is the link between vitamin D and tuberculosis? : review
|Article Title||What is the link between vitamin D and tuberculosis? : review|
|© Publisher:||Medpharm Publications|
|Journal||Southern African Journal of Epidemiology and Infection|
|Affiliations||1 St Raphael of St Francis Hospital Nsambya, Uganda, 2 Makerere University College of Health Sciences, Uganda and 3 Makerere University College of Health Sciences, Uganda|
|Publication Date||Jan 2013|
|Pages||192 - 196|
|Keyword(s)||Calcitriol, Tuberculosis and Vitamin D|
Tuberculosis is one of the leading causes of morbidity and mortality globally. Vitamin D directly influences the body's immunological response to tuberculosis by modulating the production of certain antimicrobial peptides and the release of cytokines. Vitamin D deficiency has been extensively described in patients with tuberculosis. Currently, it is a recognised risk factor for tuberculosis. Genetic polymorphisms of the vitamin D receptor may influence host susceptibility to tuberculosis and response to antituberculosis therapy. This review article explores the close association between tuberculosis and vitamin D, with the aim of forming a strong basis for further interventional and genetic studies on patients with active tuberculosis.
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