oa Southern African Journal of Infectious Diseases - Preventive therapy for children following contact with a tuberculosis source case : cause for debate in a high-burden setting? : opinion papers

Volume 29, Issue 3
  • ISSN : 2312-0053



The identification of vulnerable children following contact with an infectious tuberculosis source case, and their subsequent treatment with effective preventive therapy, reduces the risk of tuberculosis disease progression. The majority of countries in the world recommend preventive therapy for young and human immunodeficiency virus-infected children, and yet in most low-resource countries, where the highest burden of tuberculosis exists, delivery is incomplete and inadequate. This opinion paper discusses the provision of preventive therapy in children living in a high-burden setting. It presents the arguments offered by both sides in the debate, and provides the evidence cited by both positions. Finally, the article suggests interventions that could be investigated to improve the uptake of preventive therapy should it be advocated.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error