oa Southern African Journal of Infectious Diseases - Colistin : our last line of defence : editorial

Volume 31, Issue 1
  • ISSN : 2312-0053



The polymyxins are a group of antibiotics which were first isolated from a spore-bearing soil bacillus, , in 1947. Colistin, also known as polymyxin E, was introduced into clinical practice over 50 years ago. Although it has remained available for use since then, it was largely shelved in the 1970s with the discovery of antibiotics that were equally or more effective but considered less toxic.

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