oa Southern African Journal of Gynaecological Oncology - Cervical cancer and human papillomavirus : South African guidelines for screening and testing : clinical guidelines
|Article Title||Cervical cancer and human papillomavirus : South African guidelines for screening and testing : clinical guidelines|
|© Publisher:||Medpharm Publications|
|Journal||Southern African Journal of Gynaecological Oncology|
|Author||Hennie Botha, Bruno Cooreman, Greta Dreyer, Gerhard Lindeque, Arrie Mouton, Franco Guidozzi, Tony Koller, Trudy Smith, Anwar Hoosen, Louis Marcus, Manivasan Moodley and Robbie Soeters|
|Publication Date||Jan 2010|
|Pages||23 - 26|
|Keyword(s)||Niehaus Dyson Lancet Laboratories, Stellenbosch University, University of Cape Town, University of KwaZulu-Natal, University of Limpopo, University of Pretoria, University of the Free State and University of the Witwatersrand|
Cervical carcinoma is still the most common cancer of women on the African continent. Mortality remains high - worldwide at 50% - mainly because of late presentation, advanced stage of disease and absence of a functioning screening process. The aetiological link between human papillomavirus (HPV) infection and cervical cancer has been well established and a number of high-risk HPV genotypes have been identified. HPV infection is the most common sexually transmitted infection (STI) in the world today - up to 80% of sexually active females will harbour HPV at some point in their lives. The majority of women will experience natural elimination of HPV infection because of an intact immune system. Persistent infection with a high risk type HPV puts women at high risk to develop precursors of cervical cancer or carcinoma itself. As part of a public health response to this serious problem, several HPV vaccines are under development. Use of vaccines still poses unanswered questions in many respects.
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