1887

oa Southern African Journal of Gynaecological Oncology - Pathology of gestational trophoblastic neoplasia : a review with recent insights : review

 

Abstract

Gestational trophoblastic neoplasia (GTN) refers to a unique and heterogeneous group of conditions demonstrating differentiation towards various components of gestational trophoblast. Variants of hydatidiform mole (HM) are considered benign, whilst choriocarcinoma (CC), placental site trophoblastic tumour (PSTT) and the more recently described epithelioid trophoblastic tumour (ETT), a variant of PSTT, are malignant gestational trophoblastic tumours (GTT). The early and reproducible pathologic diagnosis of the various forms of GTN has been aided by recent developments in tumour markers, laboratory technology and new insights into our understanding of these different gestational diseases. Whilst CC is usually exquisitely chemosensitive, the much rarer PSTT and ETT require primary surgical management for optimal outcome. This dichotomous approach to the management of malignant GTT, determined by FIGO stage and differing tumour biology based on histology, has ensured an overall cure rate in excess of 90% for this group of tumours.

Loading

Article metrics loading...

/content/mp_sajgo/2/2/EJC80987
2010-01-01
2016-12-08
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error