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oa Southern African Journal of Gynaecological Oncology - The impact of HIV infection on women receiving radiation for cervical cancer : original research

 

Abstract

The objective of the study was to compare patient characteristics, treatment toxicity and interruptions, and survival in human immunodeficiency virus (HIV)-positive and HIV-negative cervical cancer patients receiving radiation as primary or adjuvant treatment.


Demographics, clinical and tumour characteristics, and the outcomes of 51 HIV-positive and 47-HIV negative consecutive cervical cancer patients were assessed and compared, including co-morbidities, performance status, treatment type and toxicities, and survival.
HIV-positive women were 13 years younger ( < 0.001), more often had anaemia ( 0.021) and needed pretreatment blood transfusion ( 0.037) more often than HIV-negative women. Performance status, kidney function, International Federation of Gynecology and Obstetrics stage, histology types and treatment intent and planning did not differ between the two groups. Treatment interruptions ( 0.004), transfusion during treatment ( 0.012), treatment toxicities ( 0.040) and average deficit ( 0.021) occurred significantly more in HIV-positive patients. Survival was significantly worse in HIV-positive women ( 0.029) and was associated with insufficient radiation ( < 0.001) and treatment interruptions ( 0.051).
In spite of being younger, the pretreatment correction of anaemia and the prescription of sufficient radiation dosages, HIV-infected cervical cancer patients experienced poorer survival. Treatment interruption and incomplete radiation contributed to poor outcomes.

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/content/mp_sajgo/7/2/EJC179455
2015-01-01
2016-12-03
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