oa Southern African Journal of Gynaecological Oncology - The impact of HIV infection on women receiving radiation for cervical cancer : original research

Volume 7, Issue 2
  • ISSN : 2074-2835
  • E-ISSN: 2220-105X



The objective of the study was to compare patient characteristics, treatment toxicity and interruptions, and survival in human immunodeficiency virus (HIV)-positive and HIV-negative cervical cancer patients receiving radiation as primary or adjuvant treatment.

Demographics, clinical and tumour characteristics, and the outcomes of 51 HIV-positive and 47-HIV negative consecutive cervical cancer patients were assessed and compared, including co-morbidities, performance status, treatment type and toxicities, and survival.
HIV-positive women were 13 years younger ( < 0.001), more often had anaemia ( 0.021) and needed pretreatment blood transfusion ( 0.037) more often than HIV-negative women. Performance status, kidney function, International Federation of Gynecology and Obstetrics stage, histology types and treatment intent and planning did not differ between the two groups. Treatment interruptions ( 0.004), transfusion during treatment ( 0.012), treatment toxicities ( 0.040) and average deficit ( 0.021) occurred significantly more in HIV-positive patients. Survival was significantly worse in HIV-positive women ( 0.029) and was associated with insufficient radiation ( < 0.001) and treatment interruptions ( 0.051).
In spite of being younger, the pretreatment correction of anaemia and the prescription of sufficient radiation dosages, HIV-infected cervical cancer patients experienced poorer survival. Treatment interruption and incomplete radiation contributed to poor outcomes.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error