oa SA Pharmaceutical Journal - More about .... menopause : clinical



Extracted from text ... SA Pharmaceutical Journal - May 2006 36 CLINICAL Reprinted with permission from CME April 2005 Vol. 23 No. 4 Oestrogens and continence Oestrogen-sensitive tissues of the bladder, urethra and pelvic floor all play an important role in the continence mechanism. Oestrogens increase urethral closure pressure and improve abdominal pressure transmission to the proximal urethra. The sensory threshold of the bladder to irritative symptoms may be raised, and over 60 years ago physicians reported the successful use of oestrogens to treat urinary incontinence. Further studies showed impressive subjective improvements of up to 70%, but initial trials took place before the widespread ..


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