oa SA Pharmaceutical Journal - Gastroprotective analgesics : clinical
NSAIDs act by inhibiting the enzyme cyclooxygenase (COX), which controls the synthesis of mediators called prostaglandins. The inhibition of prostaglandin synthesis results in the suppression of inflammation and effective analgesia. Most NSAIDs, however, not only inhibit prostaglandins at sites of inflammation, but also inhibit the prostaglandins, which serve important functions, in other parts of the body. The suppression of prostaglandins at these sites can produce GI and renal toxicity and impair normal platelet function.
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