oa SA Pharmaceutical Journal - Oral hypoglycaemic drugs and newer agents use in type 2 diabetes mellitus : clinical

Volume 75, Issue 9
  • ISSN : 2221-5875
  • E-ISSN: 2220-1017



We have reviewed the use of oral agents in the management of type 2 diabetes, together with their pharmacological mechanisms, indications, side effects and contra-indications. The principal oral agents available for use include metformin, sulphonylureas, non-sulphonylurea secretagogues (), thiazolidinediones, and -glucosidase inhibitors. More recently, DPP-IV inhibitors and glucagon-like peptide-1 agents have been registered for use in the United States and in Europe. They await Medicines Control Council registration for use in South Africa.

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