oa SA Pharmaceutical Journal - Evidence-based pharmacy practice (EBPP) : peptic ulcer disease : review
Peptic ulcer is an erosion in a segment of the gastrointestinal mucosa, typically in the stomach (gastric ulcer) or the first few centimeters of the duodenum (duodenal ulcer), that penetrates through the muscularis mucosae. Symptoms typically include burning epigastric pain that is often relieved by food.
Nearly all ulcers are caused by Helicobacter pylori (H pylori) infection or non-steroidal anti-inflammatory drug (NSAID) use. H pylori has been clearly associated with both gastric and duodenal ulcers, and, in the absence of NSAIDs, eradication of the organism results in long-term healing with re-infection being rare. H pylori is said to account for 80% of all gastric or stomach ulcers and more than 90% of all duodenal ulcers. Confirmation of the presence of H pylori prior to eradication therapy is recommended.
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