oa SA Pharmaceutical Journal - Evidence-based pharmacy practice (EBPP) : peptic ulcer disease : review

Volume 76, Issue 1
  • ISSN : 2221-5875
  • E-ISSN: 2220-1017



Peptic ulcer is an erosion in a segment of the gastrointestinal mucosa, typically in the stomach (gastric ulcer) or the first few centimeters of the duodenum (duodenal ulcer), that penetrates through the muscularis mucosae. Symptoms typically include burning epigastric pain that is often relieved by food.

Nearly all ulcers are caused by infection or non-steroidal anti-inflammatory drug (NSAID) use. has been clearly associated with both gastric and duodenal ulcers, and, in the absence of NSAIDs, eradication of the organism results in long-term healing with re-infection being rare. is said to account for 80% of all gastric or stomach ulcers and more than 90% of all duodenal ulcers. Confirmation of the presence of prior to eradication therapy is recommended.

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