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oa SA Pharmaceutical Journal - S-nitrosylation and its influence on the calcium channel activity of polycyclic cage amines

 

Abstract

The novel compounds synthesised in this study are now proven nitrosylators and comply with the structural requirements for NMDA receptor antagonism. It can therefore be postulated that they show promise as potential drug leads in the treatment of neurodegenerative diseases. A calcium flux assay is currently underway to unambiguously prove whether or not S-nitrosylation does in fact augment the calcium channel activity of polycyclic cage amines.

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/content/mp_sapj/76/2/EJC82113
2009-03-01
2016-12-03
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