oa SA Pharmaceutical Journal - A perspective on anxiolytics : review

Volume 76, Issue 7
  • ISSN : 2221-5875
  • E-ISSN: 2220-1017



Anxiety is a feeling of unease or disquiet in response to a perceived threat. Activation of neurobiological systems initiate a cascade of events which cause these apprehensive feelings as well as a cluster of physical symptoms including (amongst others) tachycardia, sweating palms, tremor, shortness of breath and restless pacing. The anxiety response is orchestrated in order to prompt us to take appropriate self-preservation action, and is a normal physiological reaction in the face of a threat. If, however, the extent of alarm is excessive in relation to the threat, or continues long after the danger has receded, then symptoms of anxiety may impair normal functioning, resulting in the diagnosis of an anxiety disorder.

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