oa SA Pharmaceutical Journal - Eflornithine derivatives for enhanced oral bioavailability in the treatment of human African trypanosomiasis : cum laude

Abstract

Human African trypanosomiasis (HAT), or sleeping sickness, is caused by the parasite protozoa Trypanosoma brucei gambiense and T.b. rhodesiense and is transmitted to humans by the tsetse fly (Glossina) which can only be found in sub-Sahara Africa between latitudes 14°N and 29°S (WHO,1998).