oa SA Pharmaceutical Journal - Rational drug use - antihypertensive therapy : review

Volume 77, Issue 3
  • ISSN : 2221-5875
  • E-ISSN: 2220-1017



Hypertension is a common condition in South Africa and is a risk factor for heart attacks, stroke, left ventricular hypertrophy, renal disease and blindness. Managing hypertension, despite the proven benefits of blood pressure control, remains a major challenge. Hypertension is also a chronic condition and therefore, when selecting antihypertensive drug therapy, health care workers must consider affordability, safety and efficacy of lifelong drug therapy. This review article discusses antihypertensive drug therapy; including individual patient factors to consider when selecting initial therapy, dosing, combination therapy and safety; so as to promote the rational use of antihypertensive therapy to achieve therapeutic goals.

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