oa SA Pharmaceutical Journal - Acid suppressants and peptic ulcer disease : review

Volume 77, Issue 3
  • ISSN : 2221-5875
  • E-ISSN: 2220-1017



Peptic ulcer disease usually occurs in the stomach and proximal duodenum. Nearly all ulcers are caused by infection or non-steroidal anti-inflammatory drug use. Symptoms typically include epigastric discomfort (e.g. pain relieved by food intake or antacids and pain that causes awakening at night or that occurs between meals). If infection is diagnosed, the infection should be eradicated and antisecretory therapy (preferably with a proton pump inhibitor) given for four weeks. Patients taking non-steroidal anti-inflammatory drugs should discontinue NSAID use if a peptic ulcer develops. The aim of PUD treatment is to neutralise or decrease gastric acidity, which promotes healing of the ulcer. A number of medicines are available to relieve symptoms, all of which are effective but vary in cost, duration of therapy, safety profiles and convenience of dosing.

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