oa SA Pharmaceutical Journal - Non-ulcerative dyspepsia : diagnosis and management : review

Volume 78, Issue 2
  • ISSN : 2221-5875
  • E-ISSN: 2220-1017



Dyspepsia is classified as non-ulcerative when no definite biochemical or structural cause for symptoms can be found after a clinically appropriate investigation has been conducted. Non-ulcerative dyspepsia (NUD) patients have a number of somatic complaints, as well as symptoms of depression and anxiety. Extensive diagnostic testing should be done in patients with serious risk factors. In patients with no risk factors, empiric therapy with an acid suppressant, prokinetic agent, or antimicrobial with activity against should be considered. Psychotropic agents should be considered for patients with co-morbid depression and anxiety. The treatment of NUD requires a fine balance between pharmacologic management of functional disease and psychological disease. Although NUD has a benign nature, it is generally a lifelong problem.

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