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oa SA Pharmaceutical Journal - The treatment of cholesterol : safety and efficacy of statin therapy : review

 

Abstract

Statins are the most widely prescribed class of drugs worldwide, and also the most powerful cholesterol-lowering drugs currently available. Statins inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG CoA) reductase, which leads to reduced cholesterol synthesis. In addition, low-density cholesterol receptors on the hepatocyte surface are upregulated, leading to increased clearance of cholesterol. Cholesterol levels are reduced, which leads to a significant reduction in cardiovascular events, of 25-45%.

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/content/mp_sapj/79/9/EJC126965
2012-10-01
2016-12-03
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