oa SA Pharmaceutical Journal - The treatment of cholesterol : safety and efficacy of statin therapy : review
|Article Title||The treatment of cholesterol : safety and efficacy of statin therapy : review|
|© Publisher:||Medpharm Publications|
|Journal||SA Pharmaceutical Journal|
|Affiliations||1 University of Pretoria|
|Publication Date||Oct 2012|
|Pages||27 - 28|
Statins are the most widely prescribed class of drugs worldwide, and also the most powerful cholesterol-lowering drugs currently available. Statins inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG CoA) reductase, which leads to reduced cholesterol synthesis. In addition, low-density cholesterol receptors on the hepatocyte surface are upregulated, leading to increased clearance of cholesterol. Cholesterol levels are reduced, which leads to a significant reduction in cardiovascular events, of 25-45%.
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