oa SA Pharmaceutical Journal - Bisphosphonates and their use : review



Bisphosphonates are a class of medicine used to treat bone disorders and malignancies associated with an increased risk of fractures. Their primary mechanism of action is inhibition of osteoclastic bone resorption. Over the past few years, a number of bisphosphonates and generics thereof have become available on the market. An increasing body of literature has suggested that their use may be associated with a variety of adverse effects. In this article, the pharmacology, mechanism of action and safety profile of bisphosphonates will be reviewed.


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